The ongoing saga of sirtuins and aging |
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Authors: | Kaeberlein Matt |
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Institution: | 1Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA |
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Abstract: | Sirtuins are known to slow aging in simple eukaryotes; however, viewing mammalian sirtuins as antiaging proteins may be overly simplistic. In this issue of Cell Metabolism, Li et al. (2008) provide evidence that SirT1 has properties consistent with both pro- and antiaging functions in mice. |
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