N-Acetylmuramyl-L-Alanyl-D-Isoglutamine Glycosides: Effect of Glycoside Bond Configuration and Aglycone on Biological Activity |
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| Authors: | Zemlyakov A E Tsikalov V V Kalyuzhin O V Kur'yanov V O Chirva V Ya |
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| Institution: | (1) Vernadsky Tauriyan National University, ul. Yaltinskaya 4, Simferopol, 95007, Ukraine;(2) Research Institute of Human Morphology, Russian Academy of Medical Sciences, ul. Tsuryupy 3, Moscow, 117418, Russia |
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| Abstract: | Hexyl, octyl, and cyclohexyl  -glycosides and heptyl and cyclohexyl  -glycosides of muramyl dipeptide (MDP) were synthesized. Tests in vitro and in vivo revealed lower immunostimulating activities of MDP -glycosides in comparison with the corresponding -glycosides and MDP itself. In the case of alkyl -glycosides, differences in hydrocarbon chain lengths (C4–C8) and in aglycone (aliphatic chain and aliphatic or aromatic ring) exerted no substantial effect on the immunostimulating activity. |
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| Keywords: | glycopeptides muramyl dipeptide muramyl dipeptide glycosides immunostimulating activity nonspecific infectious resistance |
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