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Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome |
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| Authors: | Richards Steven Sorensen Bryan Jae Hwan-Soo Winn Marty Chen Yixian Wang Jiahong Fung Steven Monzon Katina Frevert Ernst U Jacobson Peer Sham Hing Link J T |
| Institution: | aMetabolic Disease Research, GPRD, Abbott Laboratories, 100 Abbott Park Rd., Abbott Park, IL 60064, USA |
| Abstract: | High throughput screening efforts have identified a novel class of dichloroaniline amide 11β-HSD1 inhibitors. SAR studies initiated from dichloroaniline 4 focused on retaining the potency and selectivity profile of the lead. |
| Keywords: | 11β-HSD1 inhibitor 11β-hydroxysteroid dehydrogenase |
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