Hyperpolarization by glucose of feeding-related neurons in snail |
| |
Authors: | Alania Magda Dyakonova Varya Sakharov D A |
| |
Institution: | Laboratory of Comparative Physiology, Institute for Developmental Biology, RAS, 26 Vavilov str., Moscow, 119909 Russia. |
| |
Abstract: | In the pond snail Lymnaea stagnalis, D-glucose action was investigated on electrical activity of identified central neurons. In the CNS preparations isolated from specimens that starved for 24-96 h, D-glucose added to a standard or HiDi saline at 500-700 microg/ml effectively hyperpolarized ca. 90% of feeding related neurons B1, SO and CGC. However, not all feeding-related neurons examined were responsive to glucose. Experiments on cells of the serotonergic Pedal A cluster have shown that hyperpolarizing action of D-glucose is retained following complete isolation of "hunger" neurons. Threshold concentration producing 1-3 mV hyperpolarization was ca. 50 microg/ml. The results suggest a direct glucose involvement in the mechanisms that control feeding behavior in Lymnaea. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|