Increase in histone acetylation and transitions in histone variants during Friend cell differentiation |
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| Authors: | J M Leiter W Helliger B Puschendorf |
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| Affiliation: | Institut für Medizinische Chemie und Biochemie der Universität, A-6020 Innsbruck, Austria |
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| Abstract: | Histone acetylation of Murine Erythroleukemia Cells (MELC) has been re-examined. It is demonstrated that sodium butyrate causes hyperacetylation of core histones in inducible as well as non-inducible MELC strains. This indicates that histone hyperacetylation per se is not sufficient to activate genes. However, [3H]acetate incorporation into core histones of the inducible MELC line F4N increases after induction of differentiation with dimethylsulfoxide (DMSO), in contrast to the non-inducible variant F4+. Thus histone acetylation may play a role as an auxiliary mechanism for gene activation (and inactivation). In addition, the appearance of a histone H3 variant during differentiation of MELC is reported. |
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| Keywords: | To whom offprint requests should be sent. Address: Institut für Medizinische Chemie & Biochemie der Universität Innsbruck Fritz-Pregl Str. 3 A-6020 Innsbruck Austria. |
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