| H9N2亚型猪流感病毒感染BALB/c小鼠动物模型的建立 |
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| 引用本文： | 魏东,刘英,徐彤. H9N2亚型猪流感病毒感染BALB/c小鼠动物模型的建立[J]. 中国实验动物学报, 2012, 0(5): 54-57,98 |
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| 作者姓名： | 魏东 刘英 徐彤 |
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| 作者单位： | 甘肃农业大学;河北北方学院 |
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| 基金项目： | 河北省自然基金(C2009001028和C2011405002) |
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| 摘 要： | 目的建立H9N2亚型猪流感病毒感染BALB/c小鼠动物模型,为研究病毒致病机制提供模型动物。方法通过滴鼻的方法将H9N2亚型猪流感病毒感染BALB/c小鼠,观察小鼠的症状和组织病理变化。结果 BALB/c小鼠的临床症状明显,病理变化典型。结论 H9N2亚型猪流感病毒感染BALB/c小鼠的疾病模型成功建立。
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| 关 键 词： | H9N2亚型猪流感病毒 BALB/c小鼠 动物模型 感染 |
Establishment of a BALB/c mouse model of swine influenza virus(H9N2) infection |
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| WEI Dong,LIU Ying,XU Tong. Establishment of a BALB/c mouse model of swine influenza virus(H9N2) infection[J]. Acta Laboratorium Animalis Scientia Sinica, 2012, 0(5): 54-57,98 |
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| Authors: | WEI Dong LIU Ying XU Tong |
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| Affiliation: | 1.Gansu Agricultural University,Lanzhou 730070,China;2.Hebei North University,Zhangjiakou 075000) |
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| Abstract: | Objective To establish an swine influenza virus(H9N2) infection model in BALB/c mice and to provide animal models for studying its pathogenetic mechanism.Methods Eighty mice were divided into experimental and control groups,40 in each group.The experimental mice were infected with swine influenza virus(H9N2) by nose dropping.Then the clinical symptoms and histopathological and ultrastructural changes were observed.Results The BALB/c mice showed clear clinical symptoms and typical pathological lesions.Conclusion A BALB/c mouse model of swine influenza virus(H9N2) infection has been successfully established. |
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| Keywords: | Swine influenza virus(H9N2) BALB/c mice Animal model Infection |
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