The transporter associated with antigen processing TAP: structure and function |
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Authors: | Lankat-Buttgereit B Tampé R |
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Affiliation: | Institut für Physiologische Chemie, Philipps-Universit?t Marburg, Karl-von-Frisch-Str. 1, 35033, Marburg, Germany. |
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Abstract: | The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance. |
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