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Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control |
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| Authors: | Veljko Veljkovic Nevena Veljkovic Claude P Muller Sybille Müller Sanja Glisic Vladimir Perovic Heinz Köhler |
| Affiliation: | 1. Center for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, P.O. Box 522, 11001, Belgrade, Serbia 2. Institute of Immunology and WHO Collaborative Center for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé Luxembourg, 20A rue Auguste Lumière, L-1950, Luxembourg, Grand-Duchy of Luxembourg 3. Immpheron Inc., 5235 Athens-Boonesboro Rd., Lexington, Kentucky, 40509, USA 4. Department of Microbiology and Immunology, University of Kentucky, Markey Cancer Center, Combs 203, 800 Rose Street, Lexington, Kentucky, 40536, USA |
| Abstract: | BackgroundEpidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the world's economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction. |
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