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Characteristics of the clinical and immunologic safety of inactivated influenza vaccines in children undergoing multiple immunizations
Authors:R I Vasil'eva  L A Merkur'eva  V G Iatsenko  A M Vasil'eva  M M Shvager
Abstract:In a strictly controlled epidemiological trial on 12,643 school children aged 11-14 years the reactogenic properties and safety of killed influenza chromatographic vaccine under the conditions of multiple immunization were studied. A single immunization dose of the vaccine (0.2 ml) contained the hemagglutinins of influenza viruses A/Philippines/82 (H3N3) and A/Kiev/59/79 (H1N1), 3.5 micrograms each. The preparation was introduced by means of a jet injector. The vaccine was shown to be clinically and immunologically safe under the conditions of the regular multiple immunization of children over the period of 4 years.
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