The tryptic peptide composition of the beta chains of hemoglobins A and B of the domestic cat (Felis catus) |
| |
Authors: | F Taketa A G Mauk M R Mauk B Brimhall |
| |
Institution: | (1) Department of Biochemistry, The Medical College of Wisconsin, 53233 Milwaukee, Wisconsin, USA;(2) Department of Biochemistry, University of Oregon Health Sciences Center, 97201 Portland, Oregon, USA |
| |
Abstract: | Summary The tryptic peptides from the
A and
B chains of cat hemoglobins A and B have been isolated and the amino acid compositions determined. Differences between the two chains were found in two peptides, T-1 (Gly Ser) and T-14 (Asn Ser and Lys Arg). The Gly Ser and Lys Arg substitutions are placed at -1 and -144 respectively from earlier work, and the third substitution, Asn Ser at -139 is suggested from this work. In addition, the presence of a blocked amino terminus in
B has been confirmed. Tentative sequences constructed by homology with known -chain structures suggest the occurrence of substitutions at
1
1 contacts in
A and
B that may be functionally significant. There are at least 18 differences in amino acid composition between cat
A and dog -chains and 22 differences between cat
A and normal adult human -chains. |
| |
Keywords: | Hemoglobin Tryptic peptides Cat (Felis catus) |
本文献已被 SpringerLink 等数据库收录! |
|