Cerebrospinal fluid viral load and intrathecal immune activation in individuals infected with different HIV-1 genetic subtypes |
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| Authors: | Abdulle Sahra Hagberg Lars Svennerholm Bo Fuchs Dietmar Gisslén Magnus |
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| Institution: | 1. Department of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.; 2. Department of Virology, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.; 3. Division of Biological Chemistry, Biocentre, Innsbruck Medical University & Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria.;University of Cape Town, South Africa |
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| Abstract: | BackgroundHIV-1 exhibits a high degree of genetic diversity and is presently divided into 3 distinct HIV-1 genetic groups designated major (M), non-M/non-O (N) and outlier (O). Group M, which currently comprises 9 subtypes (A-D, F-H, J and K), at least 34 circulating recombinant forms (CRFs) and several unique recombinant forms (URFs) is responsible for most of the HIV-1 epidemic. Most of the current knowledge of HIV-1 central nervous system (CNS) infection is based on subtype B. However, subtypes other than subtype B account for the majority of global HIV-1 infections. Therefore, we investigated whether subtypes have any influence on cerebrospinal fluid (CSF) markers of HIV-1 CNS infection.Methodology/Principal FindingsCSF HIV-1 RNA, CSF neopterin and CSF white blood cell (WBC) count were measured in patients infected with different HIV-1 subtypes. Using multivariate regression analysis, no differences in the CSF WBC count, neopterin and viral load were found between various HIV-1 subtypes.ConclusionsWe did not find any subtype-dependent differences in the markers evaluated in this study. |
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