Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex |
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| Authors: | Wenying Shou Ramzi Azzam Susan L Chen Michael J Huddleston Christopher Baskerville Harry Charbonneau Roland S Annan Steve A Carr Raymond J Deshaies |
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| Affiliation: | (1) Division of Biology, California Institute of Technology, Pasadena, California 91125, USA;(2) Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA;(3) Department of Computational and Structural Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA;(4) Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA;(5) Millennium Pharmaceuticals, Cambridge, Massachusetts 02139, USA |
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| Abstract: | Background In S. cerevisiae, the mitotic exit network (MEN) proteins, including the Polo-like protein kinase Cdc5 and the protein phosphatase Cdc14, are required for exit from mitosis. In pre-anaphase cells, Cdc14 is sequestered to the nucleolus by Net1 as a part of the RENT complex. When cells are primed to exit mitosis, the RENT complex is disassembled and Cdc14 is released from the nucleolus. |
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