Differential Expression of Type A and Type B Monoamine Oxidase of Mouse Astrocytes in Primary Cultures |
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| Authors: | P. H. Yu L. Hertz |
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| Affiliation: | Psychiatrie Research Division, University Hospital, Saskatoon, Saskatchewan, Canada;Department of Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada |
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| Abstract: | Abstract: Type A and type B monoamine oxidase (MAO) activities were determined in mouse brain and in primary cultures of mouse astrocytes. Thirty-one-day-old astrocyte cultures exhibited predominantly type A MAO activity. In cultures of the same age, treated with 0.25 mM dibutyryl cyclic AMP under the same culturing conditions, 30% type B MAO was expressed, although dibutyryl cyclic AMP up to 1 mM does not affect MAO activity in vitro. The specific activity of type B MAO increased significantly in older cultures, while type A MAO changed only slightly. |
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| Keywords: | MAO-A MAO-B Astrocytes Dibutyryl cyclic AMP |
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