Sulfur amino acid metabolism in the developing rhesus monkey brain: Interrelationship of taurine and glutamate |
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| Authors: | David K Rassin John A Sturman Gerald E Gaull |
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| Institution: | (1) Department of Human Development and Nutrition, New York State Institute for Basic Research in Mental Retardation, 10314 Staten Island, New York;(2) Department of Pathological Neurobiology, New York State Institute for Basic Research in Mental Retardation, 10314 Staten Island, New York;(3) Present address: Division of Developmental Nutrition and Metabolism, Department of Pediatrics, University of Texas Medical Branch, 77550 Galveston, TX |
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| Abstract: | The relationship of taurine to glutamate, and to other amino acids, has been examined in the occipital lobe of the developing rhesus monkey. During development taurine decreases in concentration (4.96  mol/g in fetus to 1.52 mol/g in adult) while glutamate increases (7.92 mol/g in fetus to 11.26 mol/g in adult). When the concentration of taurine is plotted against that of glutamate in fetal, neonatal and adult animals there is a significant correlation in the fetal (p<0.01) and adult (p<0.01) but not in the neonatal occipital lobe samples. This correlation in both fetal and adult brain is specific for these two amino acids. Subcellular fractionation studies further indicate that this relationship may be of special importance in nerve endings.This paper is dedicated to Dr. Derek Richter on his seventy-fifth birthday. |
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