New allergies after cord blood transplantation |
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| Authors: | Leigh Ann Vaughan Mary Vu Salyka Sengsayadeth Catherine Lucid Carey Clifton Karen Mccarty David Hagaman Jennifer Domm Adetola Kassim Wichai Chinratanalab Stacey Goodman John Greer Haydar Frangoul Brian G Engelhardt Madan Jagasia Bipin N Savani |
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| Institution: | 1. Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA;2. Vanderbilt Asthma, Sinus, and Allergy Program (VASAP), Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA;3. Pediatric Stem Cell Transplant Program, Monroe Carell Jr. Children''s Hospital Vanderbilt University Medical Center, Nashville, Tennessee, USA;1. Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom;2. NHS Blood and Transplant Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom;3. Cancer and Haematology Centre, Churchill Hospital, Oxford, United Kingdom;1. Department of Hepatobiliary Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People''s Republic of China;2. Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People''s Republic of China;3. Department of Pathology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People''s Republic of China;1. Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;2. Department of Dermatology, Chosun University Medical School, 588 Seosuk-dong, Dong-gu, Gwangju, Republic of Korea;1. Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan;2. Section of Dermatology, Shimada Municipal Hospital, 1200-5 Noda, Shimada 427-8502, Japan;1. Chair of Geriatrics, University of Cologne, Cologne, Germany;2. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany;1. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN;2. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN;3. Departments of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN;4. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN |
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| Abstract: | Background aimsUmbilical cord blood transplantation (CBT) is an effective treatment for benign and malignant diseases. Late effects of CBT are not well described in the literature. In the present study, we present our experience of new-onset allergies in long-term survivors after CBT.MethodsAfter an initial patient had a severe peanut allergic reaction after CBT, all CBT patients were prospectively followed for new allergy development. Fifty patients received CBT between March 2006 and June 2011.ResultsThe median follow-up after CBT was 447 days (range, 12–2022). At the time of analysis, 30 patients were alive, with 3-year survival of 55.5%; median follow-up of surviving patients was 910 days (range, 68–2022). The allergic syndrome developed in five patients, with the cumulative incidence of new allergies at 2 years of 18.4% (95% confidence interval, 10.8–26). The median time to onset of new allergy after transplantation was 298 days (range, 250–809).ConclusionsAllergy development has been linked to a delayed maturation of the immune system in several studies. We present the first case series of patients who had new allergies after CBT. Further study of this novel complication as well as counseling of patients after CBT would be important. |
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| Keywords: | allergies cord blood transplantation hematological malignancies |
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