In vivo properties of some new cis-platinum complexes containing 7-azaindole ligands |
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| Authors: | Roger C Harrison Charles A McAuliffe Michael E Friedman |
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| Institution: | 1. Department of Chemistry of University of Manchester Institute of Science and Technology, Manchester M60 1QD, U.K.;2. Auburn University, Auburn, Ala. 36849, U.S.A. |
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| Abstract: | Toxicity data and some preliminary antitumor testing results are reported for the new complexes cis-PtLX2 (L = 1H-pyrrolo2,3-b]pyridine, (7-azaindole); X2 = Cl2, I2 oxalate). Although these complexes have the cis-PtN2X2 configuration recognised as desirable for effective antitumor behavior, no significant antitumor properties were observed against a number of primary screens; although interesting toxicity differences were observed between the three compounds. |
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| Keywords: | Author to whom correspondence should be addressed |
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