Antitumor activity and metal complexes of the first transition series. Trans-bis(salicylaldoximato)copper(II) and related copper(II) complexes,a novel group of potential antitumor agents |
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| Authors: | Paavo Lumme Hannu Elo Juhani Jänne |
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| Institution: | Department of Inorganic Chemistry, University of Helsinki, Vuorik. 20, SF-00100 Helsinki, Finland;Department of Biochemistry, University of Helsinki, Unionink. 35, SF-00170 Helsinki, Finland |
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| Abstract: | The antitumor activity of forty nine different metal complexes of the first transition series against mouse leukemia L 1210 cells and of two of the complexes against Ehrlich ascites carcinoma have been tested in vitro by the method described in this paper. Eight complexes showed a 50% inhibition of tumor cell division at concentration level 5–6 μg/ml of the complex for the former and two most effective complexes also for the latter. The trans-bis-(salicylaldoximato)copper(II) and trans-bis(resorcylaldoximato)copper(II) complexes were found to possess the highest antitumor activity. |
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| Keywords: | Author to whom correspondence should be addressed |
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