The complexation of transition series metal ions by nalidixic acid |
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| Authors: | A. Cole J. Goodfield D.R. Williams J.M. Midgley |
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| Affiliation: | Department of Applied Chemistry, University of Wales Institute of Science and Technology, Cardiff CF1 3NU, U.K.;Department of Pharmaceutical Chemistry, The School of Pharmacy, University of London, London WCIn 1AX, U.K. |
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| Abstract: | The following formation constants have been determine for nalidixic acid: proton, copper(II) complexation, magnesium(II) complexation, guanosine-5′-monophosphate-copper(II) complexation. Use of these data (together with the corresponding published constants of calcium(II), iron(II), manganese(II) and zinc(II) supports the hypothesis that the drug acts at a site other than extracellular. Complex formation between nalidixic acid, metal ion and DNA (at guanosine residues) is suggested. |
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| Keywords: | Author to whom correspondence should be addressed. |
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