Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase |
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Authors: | Kwon Yong-Uk Im Jungkyun Choi Gildon Kim Young-Soo Choi Kwan Yong Chung Sung-Kee |
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Affiliation: | Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science & Technology, Pohang 790-784, South Korea. |
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Abstract: | scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P(2), scyllo-I(1,2,4)P(3), scyllo-I(1,2,3,4)P(4). We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed. |
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