Cell surface proteins and malignant transformation |
| |
Authors: | Richard O Hynes |
| |
Institution: | Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass. 02139 U.S.A. |
| |
Abstract: | Many of the altered properties of malignant cells are thought to involve alterations in cell surface functions. In order to understand these alterations it is necessary to know more about the molecular structure of the surface. Methods for analyzing surface proteins are discussed and their application to normal and transformed tissue culture cells are reviewed. A number of surface proteins are observed to be altered by transformation. Most of the alterations are reductions in amounts of particular species, although a few proteins do increase. Evidence concerning the reasons for these alterations and the possible functions of some of the molecules is reviewed. Working hypotheses arising from these data are presented and prospects for understanding the physiological changes in terms of molecular effects are discussed. Particular emphasis is placed on the idea that surface molecules are associated in specific-non-covalent complexes which are important for their functions. |
| |
Keywords: | CEF chicken embryo fibroblasts RSV CEF Rous sarcoma virus-transformed CEF ts temperature sensitive TLCK tosyl lysyl chloromethyl ketone Virus nomenclature is given in Table I and nomenclature of surfacr proteins and antigens is given in the tables and in Section III of the text |
本文献已被 ScienceDirect 等数据库收录! |