Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility |
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| Authors: | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun |
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| Institution: | 1.Center for Reproductive Medicine, Department of Obstetrics and Gynecology,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China;2.Clinical Center for Stem Cell Research,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China;3.Department of Obstetrics and Gynecology,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China;4.State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing,China |
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| Abstract: | Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. |
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