Induction of macrophage antiprotozoal activity by monocyte chemotactic and activating factor |
| |
| Authors: | Sharon B Mannheimer June Hariprashad Mark Y Stoeckle Henry W Murray |
| |
| Institution: | Division of Infectious Diseases, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA |
| |
| Abstract: | Abstract To determine if monocyte chemotactic and activating factor (MCAF) induces intracellular antimicrobial activity, human monocyte-derived macrophages were treated with MCAF and challenged with Toxoplasma gondii and Leishmania donovani . Pretreatment with MCAF induced macrophages to inhibit protozoal replication by approximately 50%. These findings suggest a potential host defense role for MCAF in the inflammatory response to intracellular pathogens. |
| |
| Keywords: | Monocyte chemotactic and activating factor Antiprotozoal activity Toxoplasma gondii Leishmania donovani |
|
