Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties |
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| Authors: | Marco Sardiello Stefano Cairo Bianca Fontanella Andrea Ballabio Germana Meroni |
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| Institution: | 1.Telethon Institute of Genetics and Medicine (TIGEM),Naples,Italy;2.Department of Pediatrics,Federico II University,Naples,Italy;3.Unite d'Oncogenèse et Virologie Moléculaire, Batiment Lwoff,Institut Pasteur,Paris Cedex 15,France;4.Department of Pharmaceutical Sciences,University of Salerno,Fisciano (SA),Italy |
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| Abstract: | Background The TRIM family is composed of multi-domain proteins that display the Tripartite Motif (RING, B-box and Coiled-coil) that
can be associated with a C-terminal domain. TRIM genes are involved in ubiquitylation and are implicated in a variety of human
pathologies, from Mendelian inherited disorders to cancer, and are also involved in cellular response to viral infection. |
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