Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02 |
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| Authors: | Usuki Yoshinosuke Mitomo Koichi Adachi Noriko Ping Xu Fujita Ken-Ichi Sakanaka Osamu Iinuma Katsuharu Iio Hideo Taniguchi Makoto |
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| Institution: | Department of Material Science, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. usuki@sci.osaka-cu.ac.jp |
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| Abstract: | Several analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were semi-synthesized for structure-activity studies. In vitro antifungal activities of these compounds against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A. |
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