The Nogo receptor complex: confining molecules to molecular mechanisms |
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Authors: | Schwab Jan M Tuli Sagun K Failli Vieri |
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Institution: | CNRS 7102, Equipe Développement Neuronal, Université Pierre et Marie Curie, 75005 Paris, France. Jschwab@zeus.bwh.harvard.edu |
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Abstract: | Myelin inhibitory ligands of the Nogo-66 receptor (NgR1) limit axon regeneration in the adult CNS. Recent findings have identified additional co-receptors (functional homologues) of the trimeric NgR1 complex, post-translational modifications of the co-receptors within the cell membrane and novel Ca(2+)-dependent cytoplasmic-protein phosphorylation mechanisms. Such unique signalling pathways provide the potential to transduce myelin-derived growth inhibitory signals to the axonal cytoskeleton, and have been areas of intense investigation in recent years. Here, we summarize current understanding of the molecular basis of myelin-derived axon-growth inhibition in the CNS. |
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