Exercise,redox system and neurodegenerative diseases |
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| Institution: | 1. Exercise and Metabolism Research Center, Zhejiang Normal University, Jinhua City, Zhejiang, China;2. Research Institute of Sport Science, University of Physical Education, Budapest, Hungary;3. Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan;4. Research Group on Biology of Exercise, Department of Health Sciences, Federal University of Santa Catarina, Santa Catarina, Brazil;5. Laboratory of Exercise Biochemistry in Health, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil;6. Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
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| Abstract: | Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways. |
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