Management of adenomas and toxic multinodular goiters with Iodine 131 |
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| Affiliation: | 1. Service de médecine nucléaire, institut universitaire du cancer Toulouse Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France;2. Service d’endocrinologie de l’hôpital Larrey, CHU de Toulouse, 24, chemin de Pouvourville - TSA 30030, 31059 Toulouse cedex 9, France;3. Service de médecine nucléaire, université de Bordeaux, hôpital Haut-Lévêque, CHU de Bordeaux, avenue Magellan, 33604 Pessac, France;4. Department of Nuclear Medicine, La Timone University Hospital, European & Center for Research in Medical Imaging, Aix-Marseille University, 13005 Marseille, France;5. Service de Biophysique et médecine nucléaire de l’hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France;1. Department of Endocrine Surgery, Third Chair of General Surgery, Jagiellonian University Medical College, 37 Prądnicka Str., 31-202 Krakow, Poland;2. Clinical Department of General Surgery and Oncology, G. Narutowicz Specialist Municipal Hospital of Krakow, 37 Prądnicka Str., 31-202 Krakow, Poland;1. Consultant (Surgery), King Hussein Medical Center, Amman 11831, Jordan;2. Senior Specialist (Pathology), King Hussein Medical Center, Amman 11831, Jordan;3. Specialist (Surgery), King Hussein Medical Center, Amman 11831, Jordan;4. Senior Specialist (Internal Medicine and Endocrinology), King Hussein Medical Center, Amman 11831, Jordan;5. Senior Resident (Surgery), King Hussein Medical Center, Amman 11831, Jordan;6. Senior Specialist (Surgery), King Hussein Medical Center, Amman 11831, Jordan;2. Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany |
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| Abstract: | In accordance with all the guidelines of the various international scientific societies, treatment using radioiodine (RAI) of autonomous toxic adenomas and toxic multinodular goiters is highly recommended and its effectiveness its efficacy has now been widely demonstrated and established. RAI treatment is effective to normalise thyroid function, remove functional autonomy and reduce thyroid volume. According to published data on several thousand patients treated with RAI, the success rates ranges between 85% and 100%. Moreover, with more than 70 years of experience, this treatment does not present any particular risk for patients. However, as regards pregnancy, there are no absolute contra-indications to radioiodine treatment. To date, these results include a relatively high rate of hypothyroidism in the long term and approximately one patient out of five treated, will require thyroid hormone substitution. It would be more effective to harmonise and work up on dosimetric personalized models allowing the calculation of the effective dose to be delivered to the autonomous nodule to be treated while preserving the normal thyroid parenchyma in order to optimise the patient's outcome and to favor extensive euthyroidism. |
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| Keywords: | Toxic adenomas Toxic multinodular goiter Radio-iodine-therapy Adénomes toxiques Goitre multinodulaire toxique Hyperthyroïdie Traitement à l’iode 131 Iode 131 |
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