A rapid protocol to evaluate coronary flow reserve with myocardial scintigraphy: A prospective study using Regadenoson |
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| Affiliation: | 1. Nuclear Medicine department, CHU de Bordeaux, avenue Magellan, 33000 Bordeaux, France;2. INCIA, UMR CNRS 5287, université Bordeaux-Segalen, 33000 Bordeaux, France;3. Cardiology department, CHU de Bordeaux, 33000 Bordeaux, France;1. Respiratory Division, McGill University Health Centre, 1001 Decarie Blvd, D05.2504 Montreal, Quebec, Canada H4A 3J1;6. Respiratory Division, McGill University Health Centre, Montreal, Quebec, Canada;1. Service de médecine nucléaire, CHU de Fort-de-France, CS 90632, 97261 Fort-de-France cedex, Martinique;2. Service de médecine nucléaire, hôpital Haut-Lévêque, université de Bordeaux, CHU de Bordeaux, avenue Magellan, 33604 Pessac, France;3. Service central de biophysique et de médecine nucléaire, université Aix-Marseille, CHU de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France;4. Service de médecine nucléaire, institut universitaire du cancer Toulouse Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France;1. Nuclear Medicine Unit, Policlinico S. Orsola Malpighi, University of Bologna, Bologna, Italy;2. Nuclear Medicine, Complejo Hospitalario de Navarra, Pamplona, Spain;3. Nuclear Medicine, Hosp. Universitario Virgen de la Arrixaca, Murcia, Spain;1. Service de médecine nucléaire, centre cardiologique du Nord, 93200 Saint-Denis, France;2. Service de médecine nucléaire, CHU de Grenoble, 38700 La-Tronche, France;3. Service de médecine nucléaire, CHU de Henri-Mondor, 94010 Créteil, France;4. Ligue contre le cancer, France;5. Service de médecine nucléaire, CHU de Cochin, 75014 Paris, France;6. Service de médecine nucléaire, CHU de Montpellier, 34090 Montpellier, France;7. Service de médecine nucléaire, CHU de Lille, 59000 Lille, France;8. Service de médecine nucléaire, institut de cancérologie privé, 34170 Castelnau-le-Lez, France;9. Service de médecine nucléaire, CH de Albi, 81000 Albi, France;10. Service de médecine nucléaire, AP–HM, 13005 Marseille, France |
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| Abstract: | Cardiac positron emission tomography (PET) is superior to single-photon emission computed tomography (SPECT) thanks to its quantitative analysis capabilities, especially for measuring myocardial blood flow (MBF) and myocardial flow reserve (MFR). The recent development of new cadmium zinc telluride (CZT) gamma cameras has enabled dynamic acquisition, allowing measurement of MBF and MFR. This prospective study aimed to determine the fastest protocol, to analyse MBF and perfusion imaging.Methods and resultsFrom February to June 2018, 10 patients were referred to our centre and prospectively enrolled in our study to evaluate the MBF and MFR, with 5 different reconstruction list-mod. The primary endpoint was to assess the reproducibility of the different reconstruction, and time of acquisition. The secondary endpoint was the evaluation of the image quality of the MPI. The 6-min tests highlighted no significant difference in the flow measurement and MFR (P = 0,15). Differences become significant by decreasing acquisition time. The image quality did not differ significantly (P = 0.6).ConclusionWe determined a fast (12mn acquisition) reliable and reproducible protocol to evaluate MBF and MFR without any loss of MPI information. |
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| Keywords: | Myocardial flow reserve MFR CZT Myocardial blood flow MBF Cardiac perfusion imaging Débits sanguins myocardiques DSM Réserve de flux myocardique RFM CZT Scintigraphie cardiaque |
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