Gene therapy in cancer |
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Authors: | Büşra Cesur-Ergün Devrim Demir-Dora |
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Affiliation: | 1. Faculty of Medicine, Department of Medical Pharmacology, Akdeniz University, Antalya, Turkey Health Sciences Institute, Department of Gene and Cell Therapy, Akdeniz University, Antalya, Turkey;2. Faculty of Medicine, Department of Medical Pharmacology, Akdeniz University, Antalya, Turkey |
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Abstract: | Gene therapy, recently frequently investigated, is an alternative treatment method that introduces therapeutic genes into a cancer cell or tissue to cause cell death or slow down the growth of the cancer. This treatment has various strategies such as therapeutic gene activation or silencing of unwanted or defective genes; therefore a wide variety of genes and viral or nonviral vectors are being used in studies. Gene therapy strategies in cancer can be classified as inhibition of oncogene activation, activation of tumor suppressor gene, immunotherapy, suicide gene therapy and antiangiogenic gene therapy. In this review, we explain gene therapy, gene therapy strategies in cancer, approved gene medicines for cancer treatment and future of gene therapy in cancer. Today gene therapy has not yet reached the level of replacing conventional therapies. However, with a better understanding of the mechanism of cancer to determine the right treatment and target, in the future gene therapy, used as monotherapy or in combination with another existing treatment options, is likely to be used as a new medical procedure that will make cancer a controllable disease. |
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Keywords: | biomedicine biotechnological drugs biotherapeutics cancer gene therapy cancer therapy CAR T cell therapy gene medicine gene therapy |
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