Subfertile couple with t(4;22)(q23;q11.2) |
| |
Authors: | Srebniak Małgorzata Popowska Lucyna Wawrzkiewicz-Witkowska Angelika Tomaszewska Agnieszka Kazmierczak Wojciech |
| |
Institution: | Department of Medical Genetics, The Medical University of Silesia, Jednosci 2, 41-208 Sosnowiec, Poland. srebna@poczta.onet.pl |
| |
Abstract: | A couple was referred for cytogenetic examination due to idiopathic miscarriages. The proband proved to be a carrier of chromosomal translocation and her partner's karyotype was found to be normal. The karyotype of the proband is 46,XX,t(4;22)(q23;q11.2) and can be regarded as a reason of fertility problems in the investigated couple. The risk of further miscarriages is high, but the risk of a progeny with abnormal karyotype is rather low, as the progeny would probably have lethal imbalances. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|