|
|||||
|
|
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists |
|
| Authors: | Yoon Taeyoung De Lombaert Stéphane Brodbeck Robbin Gulianello Michael Chandrasekhar Jayaraman Horvath Raymond F Ge Ping Kershaw Mark T Krause James E Kehne John Hoffman Diane Doller Darío Hodgetts Kevin J |
| Affiliation: | Neurogen Corporation, 35 North East Industrial Road, Branford, CT 06405, USA. |
| Abstract: | The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |