N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents |
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| Authors: | Matesic Lidia Locke Julie M Bremner John B Pyne Stephen G Skropeta Danielle Ranson Marie Vine Kara L |
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| Institution: | School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia. lm66@uow.edu.au |
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| Abstract: | A range of N-phenethyl, N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared by N-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma (MDA-MB-231) cell lines was assessed. The results allowed further development of structure-activity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM. |
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