Functional Compartmentalization of the Translation Apparatus and Channeling of tRNA/Aminoacyl-tRNA in Cells of Higher Eukaryotes |
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Authors: | Negrutskii B. S. El'skaya A. V. |
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Affiliation: | (1) National Academy of Sciences of Ukraine, Institute of Molecular Biology and Genetics, Kiev, 03143, Ukraine |
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Abstract: | Literature data and authors' results on the structural and functional organization of the translation apparatus in higher eukaryotes are considered. Proofs are presented of the channeling of tRNA/aminoacyl-tRNA in the course of eukaryotic protein synthesis. The concept of the shuttle role of eEF1A is grounded; the factor, being in a GTP-bound form, delivers aminoacyl-tRNA to the ribosome and then, in the having undergone to a GDP -form after hydrolysis of GTP on the ribosome, forms a complex with the deacylated tRNA and delivers it to the aminoacyl-tRNA synthetase. The notion of a translational compartment is defined. |
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Keywords: | tRNA aminoacyl-tRNA synthetases channeling compartmentalization elongation factors protein biosynthesis |
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