COX-2和Survivin在B细胞非霍奇金淋巴瘤中的表达及意义

目的:探讨COX-2和Survivin在B细胞非霍奇全淋巴瘤(B-NHL)中的表达及临床意义.方法:采用免疫组化SP法检测43例B-NHL和10例良性淋巴结病变组织中COX-2和Survivin的表达.结果:COX-2和Survivin在B-NHL中的阳性表达率分别为55.8%(24/43)和69.8%(30/43),与对照组相比差异具有显著性(P＜0.05.Ⅲ/Ⅳ期B-NHL患者COX-2蛋白的表述要高于Ⅰ/Ⅱ期患者(P＜0.05).Survivin的表达与B-NHL的组织病理学等级和国际预后指数(IPL)具有相关性(P＜0.05).Spearman相关分析表明COX-2的表达与Survivin的表达呈正相关(r=1.000,P=0.030).结论:COX-2和Survivin在B-NHL中表达上调以及两者之间的阳性表达密切相关,表明COX-2和Survivin在B-NHL的发生和发展中具有协同作用.

Expression and clinical significance of COX-2 and Survivin in B cell non-Hodgkin's lymphoma

Objective:To investiga te the expression and clinical significance of cyelooxygenase-2 (COX-2) and Survivin in B cell non-Hodgkin's lymphoma (B-NHL).Methods:The expression of COX-2 and Survivin in 43 cases of B-NHL and 10 cases of benign lymph node lesions were detected by immunohistochemical streptavidin-biotin peroxidase method.Results:The expression rate of COX-2 and Survivin in B-NHL was 55.8% (24/43) and 69.8% (30/43) respectively.Compared with the control,the difference was statistically significance (P＜0.05 and 0.01 respectively).The expression of COX-2 in patients with stage Ⅲ/Ⅳ was higher than that of patients with stage Ⅰ/Ⅱ (P＜0.05).The expression of Survivin was related with histopathologic grade and International Prognostic Index (IPI) of B-NHL (P＜0.05 and 0.01 respectively).Spaarman's correlation analysis showed COX-2 expression was positively correlated with Survivin expression(r=1.000,P=0.030).Conclusions:The specific up-regulation of COX-2 and Survivin in B-NHL and the positive correlation between expression of COX-2 and Survivin showed that they had an synergistic effect in the development and progression of B-NHL.