Associations of rs3740677 within <Emphasis Type="Italic">GAB2</Emphasis> Gene with LOAD in Chinese Han Population |
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Authors: | Jing-Yu Zheng Hui-Fu Wang Yu Wan Meng-Shan Tan Chen-Chen Tan Lin Tan Wei Zhang Zhan-Jie Zheng Ling-Li Kong Zi-Xuan Wang Lan Tan Jin-Tai Yu |
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Institution: | 1.Department of Neurology, Qingdao Municipal Hospital, School of Medicine,Qingdao University,Qingdao,China;2.College of Medicine and Pharmaceutics,Ocean University of China,Qingdao,China;3.Department of Geriatric,Qingdao Mental Health Center,Qingdao,China;4.Memory and Aging Center, Department of Neurology,University of California,San Francisco,USA |
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Abstract: | GRB2-associated binding protein 2 (GAB2) has been identified as a crucial factor in Alzheimer’s disease (AD), and ten common variants within GAB2 have been detected to be associated with AD onset risk in genome-wide association studies (GWAS). Here, we first screened a common locus (rs3740677) in 3′ UTR of GAB2 sequence which is targeted by the miRNA-185 and initiatively explored the probable associations of rs3740677 with risk for late-onset AD (LOAD) in a large scale case–control study from Chinese Han populations (992 LOAD patients and 1358 healthy subjects). Eventually, the genotype (P?=?0.024) and allele (P?=?0.008) distribution of rs3740677 showed significant difference between LOAD and control group, and we observed a significant association of T allele in rs3740677 with LOAD risk in multivariate analysis and it decreased the risk for LOAD (dominant: OR?=?0.831, 95 % CI?=?0.702–0.983, P?=?0.031; additive: OR?=?0.855, 95 % CI?=?0.745–0.983, P?=?0.027) adjusted for age, gender, and APOE ε4 status. Our study further confirmed the association of GAB2 and AD. However, the absolute and correct association of rs3740677 with AD still required more investigations in diverse regions and ethnics. |
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