首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Effects of Common Polymorphisms in the MTHFR and <Emphasis Type="Italic">ACE</Emphasis> Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis
Authors:Shuai Wu  Yan Han  Qiang Hu  Xiaojie Zhang  Guangcheng Cui  Zezhi Li  Yangtai Guan
Institution:1.Department of Neurology, Shanghai Changhai Hospital,Secondary Military Medical University,Shanghai,China;2.Department of Psychology,Qiqihar Mental Health Center,Qiqihar,China;3.Department of Pathology,Qiqihar Medical University,Qiqihar,China;4.Mental Health Institute,Qiqihar Medical University,Qiqihar,China;5.Department of Neurology, Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
Abstract:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T and ACE I/D polymorphisms and DPN found in various types of electronic databases. Strengthening the Reporting of Observational studies in Epidemiology (STROBE) quality score systems were used to determine the quality of the articles selected for inclusion. Odds ratios (ORs) and its corresponding 95 % confidence interval (95 % CI) were calculated. We used STATA statistical software (version 12.0, Stata Corporation, College Station, TX, USA) to deal with statistical data. Our results indicated an association of ACE D>I mutation (OR?=?1.43, 95 % CI 1.12–1.83, P?=?0.004) and MTHFR 677 C>T mutation (OR?=?1.43, 95 % CI 1.08–1.90, P?=?0.014) with DPN under the allele model, and similar results were also found under the dominant model (all P?<?0.05). Subgroup analysis by country indicated that the MTHFR 677 C>T polymorphism may be the main risk factor for DPN in Turkey under four genetic models. ACE D>I mutation was correlated with DPN in Japanese and Pakistani populations in the majority of groups. The relationships of MTHFR 677 C>T and ACE I/D polymorphisms with DPN patients presented in this meta-analyses support the view that the MTHFR and ACE genes might play an important role in the development of DPN.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号