In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes |
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| Authors: | Hui-Young Lee Kyeong-Hoon Jeong Cheol Soo Choi International Mouse Phenotyping Consortium |
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| Institution: | 1. Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-Gu, Songdo-Dong 7-45, Incheon, 406-840, Korea
2. Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Namdong-Gu, Guwol-Dong 1198, Incheon, 405-760, Korea
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| Abstract: | The world-wide prevalence of obesity and diabetes has increased sharply during the last two decades. Accordingly, the metabolic phenotyping of genetically engineered mouse models is critical for evaluating the functional roles of target genes in obesity and diabetes, and for developing new therapeutic targets. In this review, we discuss the practical meaning of metabolic phenotyping, the strategy of choosing appropriate tests, and considerations when designing and performing metabolic phenotyping in mice. |
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