The cytogenetic evaluation of in vivo genotoxic and cytotoxic activity using rodent somatic cells |
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Authors: | Raymond R Tice |
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Institution: | (1) Medical Department, Brookhaven National Laboratory, Upton, New York;(2) Medical Department, Brookhaven National Laboratory, 11973 Upton, NY |
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Abstract: | With the growing realization that in vitro short-term tests for genotoxicity can never fully mimic in vivo conditions, the evaluation of genotoxic damage in somatic cells of rodents has played an increasingly important role in assessing the carcinogenic potential of suspect compounds. Among the various genotoxic endpoints assessed in in vivo somatic cell assays, cytogenetic endpoints (e.g., chromosomal aberrations, micronuclei, sister chromatid exchanges) continue to be used most frequently. The purpose of this paper is to demonstrate the utility of evaluating different cytogenetic endpoints in the same animal, using as examples studies to evaluate the in vivo genotoxic potential of benzene, of methylisocyanate, and of butadiene, chloroprene and isoprene.Abbreviations CA
chromosomal aberrations
- MI
mitotic index
- MIC
methylisocyanate
- MN-NCE
micronucleated monochromatic erythrocytes
- MN-PCE
micronucleated polychromatic erythrocytes
- SCE
sister chromatid exchange |
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Keywords: | benzene butadiene chloroprene cytogenetic endpoint isoprene methylisocyanate somatic cells |
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