PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches |
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| Authors: | Giovanni Ligresti Loredana Militello Linda S. Steelman Andrea Cavallaro Francesco Basile Ferdinando Nicoletti Franca Stivala James A. McCubrey Massimo Libra |
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| Affiliation: | 1.Department of Biomedical Sciences; University of Catania; Catania, Italy;2.Brody School of Medicine at East Carolina University; Department of Microbiology and Immunology; Greenville, NC USA;3.Department of Surgery; University of Catania; Catania, Italy |
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| Abstract: | Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis. Activating mutations of the p110α subunit of PI3K (PIK3CA) have been identified in a broad spectrum of tumors. Analyses of PIK3CA mutations reveals that they increase the PI3K signal, stimulate downstream Akt signaling, promote growth factor-independent growth and increase cell invasion and metastasis. In this review, we analyze the contribution of the PIK3CA mutations in cancer, and their possible implications for diagnosis and therapy. |
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| Keywords: | PIK3CA gene mutations PI3K pathway AKT cancer |
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