Enzymatic Separation and Resolution of Nucleophiles: A Predictive Kinetic Model |
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Authors: | G Langrand J Baratti G Buono C Triantaphylides |
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Abstract: | Analysis of nucleophile separation via lipase catalyzed reactions has been developed on the basis of competitive enzymatic kinetics. Ester synthesis as well as ester interchange reactions catalyzed by lipases in organic media have been analyzed according to a transfer reaction of the acyl group from/to the enzyme. The reversible reactions are conveniently simulated from the knowledge of the a competitive factor of the enzymatic system and of the final equilibrium conditions. The model which is proposed describes the reaction profile in a predictive way. Modelling of alcohol kinetic separation and resolution is given. |
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Keywords: | Lipase competition enzymes in organic solvent reversible reactions quantitative analysis resolution of alcohols |
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