DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions |
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Authors: | Pöhlmann S Leslie G J Edwards T G Macfarlan T Reeves J D Hiebenthal-Millow K Kirchhoff F Baribaud F Doms R W |
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Affiliation: | Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. |
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Abstract: | The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface. |
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