DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions |
| |
| Authors: | Pöhlmann S Leslie G J Edwards T G Macfarlan T Reeves J D Hiebenthal-Millow K Kirchhoff F Baribaud F Doms R W |
| |
| Institution: | Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. |
| |
| Abstract: | The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
