Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents |
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| Authors: | Kamal Ahmed Ramesh G Ramulu P Srinivas O Rehana Tasneem Sheelu G |
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| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.ap.nic.in |
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| Abstract: | Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that possess cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies. |
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