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Reduced levels of two modifiers of epigenetic gene silencing,Dnmt3a and Trim28, cause increased phenotypic noise |
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| Authors: | Nadia C Whitelaw Suyinn Chong Daniel K Morgan Colm Nestor Timothy J Bruxner Alyson Ashe Eleanore Lambley Richard Meehan Emma Whitelaw |
| Institution: | (1) Genetics and Population Health, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland, 4006, Australia;(2) School of Medicine, University of Queensland, 288 Herston Road, Brisbane, Queensland, 4001, Australia;(3) MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Crewe Road, Edinburgh, EH4 2XU, UK;(4) Breakthrough Research Unit, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK |
| Abstract: | BackgroundInbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process. |
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