siRNA delivery technologies for mammalian systems |
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| Institution: | 2. Department of Cardiology, Zhengzhou University, People’s Hospital, Zhengzhou, People’s Republic of China;3. Jefferson Medical College, Philadelphia, Pennsylvania;4. Hubei University of Arts and Science, Hubei, People’s Republic of China;2. Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;3. Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan;4. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California;5. Institute of Biomedical Engineering, National Chiao-Tung University, Hsin-Chu, Taiwan;11. Cardiovascular Research Center, Department of Physiology, Section of Clinical Cardiac Electrophysiology, Philadelphia, Pennsylvania,;12. Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania;1. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. The 404 Limited, China National Nuclear Corporation, Lanzhou 732850, China |
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| Abstract: | Inhibition of gene expression using the RNA interference (RNAi) pathway is rapidly becoming the method of choice for studying gene function in mammalian cells. However, successful knockdown of the target gene requires efficient delivery of short interfering RNAs (siRNAs). Several technologies have been developed that enable effective delivery of siRNAs to both cells in culture and whole animals. These technologies will allow the use of RNAi to study gene function in mammalian model systems in which classical methods are often limited and costly. |
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