Bioluminescent indicators for in vivo measurements of gene expression |
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| Affiliation: | 1. Emergency Department, General University Hospital of Elda, Elda, Alicante, Spain;2. Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Alicante, Spain;3. Department of Medical Devices, Spanish Agency of Medicines and Medical Devices, Madrid, Spain;2. Department of Oral and Maxillofacial Surgery, Hadassah and Hebrew University Medical Center, Jerusalem, ISRAEL;3. Earle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, OR;4. The Oregon Clinic, Portland, OR |
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| Abstract: | Recent developments in in vivo imaging using optical, radionuclide and paramagnetic reporter probes now enables continuous measurements of gene expression in living animals. In vivo bioluminescence imaging (BLI) is a sensitive, versatile and accessible imaging strategy that has been applied to a variety of small-animal models of human biology and disease. We discuss current strategies in BLI and the potential of combining BLI with other in vivo and ex vivo techniques. BLI will have a significant role in in vivo cellular and molecular imaging, a field that will help reveal the molecular basis of biology and disease. |
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