Amplified genes as therapeutic targets in cancer |
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| Institution: | 1. Translational Genomics Research Institute (TGEN) Cancer Drug Development Laboratory 20 Firstfield Road, Suite 110, Gaithersburg, MD 20898, USA;2. Medical Genetics BranchNational Human Genome Research Institute, NIH, Bethesda, MD 20892, USA;3. Medical Biotechnology GroupVTT Technical Research Centre of Finland and University of Turku, P.O. Box 106, 20521 Turku Finland;4. Translational Genomics Research Institute (TGEN)Cancer Drug Development Laboratory20 Firstfield Road, Suite 110, Gaithersburg MD 20898, USA;1. International Potato Center, Nairobi, Kenya;2. International Potato Center, Kampala, Uganda;3. International Potato Center, Maputo, Mozambique;4. International Potato Center, Kumasi, Ghana;5. International Food Policy Research Institute, Kampala, Uganda;1. Landscape Dynamics and Social Processes Group, Instituto de Ciências Agrárias e Ambientais Mediterrânicas (ICAAM), University of Évora, Núcleo da Mitra, Edifício Principal, Apartado 94, 7002-554 Évora, Portugal;2. Transdisciplinarity Lab USYS TdLab, Department of Environmental Systems Science, ETH Zurich, Switzerland;3. Instituto de Ciências Sociais, Universidade de Lisboa, Portugal;4. Geography and Resource Management, The Chinese University of Hong Kong, Hong Kong;5. SOCIUS/Instituto Superior de Economia e Gestão, Universidade de Lisboa, Lisbon, Portugal;1. Emotion and Pain Laboratory, San Francisco Veterans Affairs Healthcare Center, 4150 Clement Street, San Francisco, CA 94121, USA;2. Department of Psychiatry, University of California San Francisco, 401 Parnassus Ave, San Francisco, CA 94143, USA;3. Department of Neurology, University of California San Francisco, 401 Parnassus Ave, San Francisco, CA 94143, USA;4. San Diego Veterans Affairs Healthcare Center, 3350 La Jolla Village Drive, San Diego, CA 92121, USA;5. Department of Psychiatry, University of California San Diego, San Diego, CA 92300, USA;1. Department of Microbiology, Guru Nanak Dev University, Amritsar, Punjab 143005, India;2. Sardar Swaran Singh National Institute of Bio-Energy, Kapurthala, Punjab 144601, India;3. Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, Sao Paulo, Brazil |
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| Abstract: | The most effective targeted cancer therapies have arisen from research into genetically altered oncogenes, including BCR-ABL, HER2, RAS and EGFR. Recent advances in cancer genetics have identified many regions of the genome that undergo amplification (increase in copy number) but, in most cases, the key oncogenic targets driving the growth and survival of cancer cells remain unknown. In this review, we discuss high-throughput technologies for the discovery of putative oncogenes, and clinical and functional validation of these genes as targets for therapy. New technologies in translational genomics facilitate the identification, validation and prioritization of candidate molecular targets for anti-cancer therapy. |
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