Curation is forever: comparative genomics approaches to functional annotation |
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| Affiliation: | 1. Fellowship for Interpretation of Genomes15W155 81st Street, Burr Ridge IL 60527, USA;2. Integrated Genomics, Inc. 2201 W. Campbell Park Drive, Chicago IL 60612, USA;3. Fellowship for Interpretation of Genomes15W155 81st Street, Burr Ridge IL 60527, USA;1. School of Agriculture and Biology, Shanghai Jiaotong University, 200240, Shanghai, PR China;2. Department of Emergency, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200240, Shanghai, PR China;3. Tongren Hospital, Shanghai Jiaotong University School of Medicine, 200240, Shanghai, PR China;4. Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai Jiaotong University, 200240, Shanghai, PR China;1. Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, South Africa;2. Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, South Africa;3. Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, South Africa;1. Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, United States;2. Department of Biological Sciences and Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID, United States;1. Department of Biochemistry, KGMU, Lucknow 226003, India;2. Department of Clinical Immunology, SGPGIMS, Lucknow 226014, India;3. Department of Cardiology, KGMU, Lucknow 226003, India;4. Department of Zoology, University of Lucknow, Lucknow 226007, India;1. Guangxi Key Laboratory of Marine Biotechnology, Guangxi Institute of Oceanology, Beihai 536000, China;2. Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animals, Guangdong Key Laboratory of Control for Diseases of Aquatic Economic Animals, Guangdong Ocean University, Zhanjiang 524088, China |
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| Abstract: | The process of deriving accurate annotations for genes in newly sequenced genomes has up to now been based largely on projection of results in one organism to genes in other organisms based on sequence similarity. We are now entering a period in which metabolic reconstructions will play an increasingly significant role. These reconstructions will support a gradual refinement of estimates of function, leading to more consistent and precise understanding. They will become key components in establishing which functional roles have not yet been connected to genes and which aspects of an organism's physiology can be understood in terms of existing functional assignments. As each refinement is made, we incrementally approach the goal of establishing a qualitative understanding of an organism in terms of its inventory of genes. |
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