扩布性阻抑与脑缺血

研究表明,扩布性阻抑（ＳＤ）不仅与脑缺血,偏头痛,癫痫,颅脑创伤等疾患有关,而且可影响睡眠类型,觉醒等生理过程。本文重点对ＳＤ与脑缺血的关系进行了综述,订 叙述了以下几个问题：（１）ＳＤ的发现及研究简史;（２）完整脑内的ＳＤ;（３）局灶性脑梗塞周围的ＳＤ。

Spreading depression and cerebral ischemia

Growing evidence indicates that spreading depression (SD) may not only relate to some diseases, including cerebral ischemia,migraine, epilepsy, traumatic brain injury and so on, but also affect the physiological courses such as sleep patterns and general arousal. In this paper we review the relationship between SD and cerebral ischemia. The following questions are discussed: (1)The discovery of SD and its brief research history; (2) SD in the intact brain; (3) Peri infarct SD in focal cerebral infarction. It is suggested that peri infarct SD contributes to the growth of focal ischemic lesions, and the suppression of SD may become a novel, even a key therapeutic approach for minimizing infarct volume and protecting ischemic neurons after focal cerebral ischemia.