Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage |
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| Authors: | Kang Kyoung Ah Lee Kyoung Hwa Chae Sungwook Koh Young Sang Yoo Byoung-Sam Kim Ju Ho Ham Young Min Baik Jong Seok Lee Nam Ho Hyun Jin Won |
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| Institution: |
a Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, South Korea
b Department of Microbiology, College of Medicine, Cheju National University, Jeju-si, South Korea
c Cosmetic R&D Center, COSMAX Inc., Gyeonggi, South Korea
d Department of Chemistry, College of Natural Sciences, Cheju National University, Jeju-si, South Korea |
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| Abstract: | In the present study, triphlorethol-A, a phlorotannin, was isolated from Ecklonia cava and its antioxidant properties were investigated. Triphlorethol-A was found to scavenge intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thus prevented lipid peroxidation. The radical scavenging activity of triphlorethol-A protected the Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2) against cell death, via the activation of ERK protein. Furthermore, triphlorethol-A reduced the apoptotic cells formation induced by H2O2. Triphlorethol-A increased the activities of cellular antioxidant enzymes like, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Hence, from the present study, it is suggestive that triphlorethol-A protects V79-4 cells against H2O2 damage by enhancing the cellular antioxidative activity. |
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| Keywords: | Triphlorethol-A oxidative stress apoptosis antioxidant enzymes |
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